We learned how to convert the pooled odds ratio from a random-effects model and subsequently calculate the number needed to treat (NNT) or harm (NNH). It’s important to understand that without knowing the event proportions in either the treatment or control groups, we cannot accurately estimate the absolute risk reduction for an individual study or for a meta-analysis. Fascinating indeed! Everyday is a school day! 🙌
Here, we have demonstrated three different methods for calculating NNT with meta-analysis data. I learned a lot from this experience, and I hope you find it enjoyable and informative as well. Thank you, @wwrighID, for initiating the discussion and providing a pivotal example by using the highest weight control event proportion to back-calculate ARR and, eventually, NNT. I also want to express my gratitude to @DrToddLee for contributing a brilliant method of pooling a single proportion from the control group for further estimation. Special thanks to @MatthewBJane, the meta-analysis maestro, for guiding me toward the correct equation to calculate event proportions, with weight estimated by the random effect model. 🙏
Immersed in gratitude and inspiration at #IDWeek2023 🌐! A massive thank you to everyone who contributed - your posts were a beacon of warmth and wisdom. 🌟 Celebrating the triumphs of award recipients 🏆, your remarkable achievements propel us all forward! Enlightened by the groundbreaking insights from new trials, we are reminded to remain humble and passionate in our continuous quest for knowledge. Together, we will continue unveiling the realms of Infectious Disease, advancing with unity and purpose!
What an incredible journey it has been! I’m thoroughly enjoying working with Stan codes, even though I don’t yet grasp all the intricacies. We’ve already tackled simple linear and logistic regressions and delved into the application of Bayes’ theorem. Now, let’s turn our attention to the fascinating world of Mixed-Effect Models, also known as Hierarchical Models
Diving into this, we’re exploring how using numbers to express our certainty/uncertainty, especially with medical results, can help sharpen our estimated ‘posterior value’ and offer a solid base for learning and discussions. We often talk about specifics like sensitivity without the nitty-gritty math, but crafting our own priors and using a dash of Bayes and visuals can really spotlight how our initial guesses shift. Sure, learning this takes patience, but once it clicks, it’s a game-changer – continuous learning for the win!